How do vector vaccines work to provide immunity?

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69th BPSC Prelims Exam Official Paper (Held On: 30 Sept, 2023)
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  1. By introducing a weakened or inactivated virus into the body
  2. By directly attacking and destroying pathogens in the body
  3. By placing the virus in a modified version of a different virus
  4.  By entering directly into the cells and enabling them to create spike proteins

Answer (Detailed Solution Below)

Option 3 : By placing the virus in a modified version of a different virus
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The correct answer is by placing the virus in a modified version of a different virus.

Key Points

  •  Vector vaccines use a harmless virus containing the nucleic acid of a disease-causing virus.
  • These modified viruses make antigens inside the host and provide protective immunity against it.

Important Points

  •  Vector vaccines, also known as viral vector vaccines, work by using a harmless virus to deliver genetic material into the body.
  • This genetic material contains instructions to produce a piece of the target pathogen (usually a virus) or a modified version of it, such as a spike protein, which is part of the virus's structure. 
  • Vector vaccines, like the Oxford-AstraZeneca, Johnson & Johnson's Janssen, and Sputnik V vaccines for COVID-19, have been effective in providing immunity against various diseases.
  • They offer several advantages, such as the ability to generate a strong and long-lasting immune response without using live or weakened pathogens, making them safer in some cases.
  • Different vector vaccines use various viral vectors and may have distinct mechanisms for delivering the genetic material, but the overall principle of using a harmless virus to trigger an immune response remains consistent.
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