The complex(es) showing activity against cancerous cells is/are

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CSIR-UGC (NET) Chemical Science: Held on (26 Nov 2020)
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  1. (a) only
  2. (a) and (b) only
  3. (a) and (c) only
  4. (a), (b) and (c)

Answer (Detailed Solution Below)

Option 4 : (a), (b) and (c)
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 Concept:

  • Platinum-based drugs are used in clinical research for cancer treatment. Cisplatin or cis-diamminedichloroplatinum(II) and its analogs are some of the most effective chemotherapeutic agents are in use for cancer treatment.
  • The square planar Pt(II) is activated by slow hydrolysis of the anionic ligands. The corresponding cationic aqua complexes are thus formed by binding to DNA. 

Explanation:

  • All of the complexes a, b, and c are thermodynamically and kinetically stable with respect to hydrolysis in blood where the concentration of Cl- ion is very high. The two Cl atoms are cis to each other in both complex a and c.
  • For complexes a and c, the bite distance between the two cis Cl ligands is appropriate to bind with DNA. So, The complex(es) showing activity against cancerous cells is/are (a) and (c).
  • Complex b is an antitumoural and antimetastatic arene ruthenium complex. The complex [(C6H5Ph)Ru(N, N-en)Cl]+ is also used as an anticancer agent.

​Conclusion:

The complex(es) showing activity against cancerous cells is/are (a), (b), and (c).

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