Who performed the transformation experiment with Streptococcus pneumoniae?

The correct answer is Frederick Griffith.

• Frederick Griffith performed this transformation experiment with Streptococcus pneumoniae in 1928.

Key Points

• In this experiment, bacteria are grown in a suitable culture medium; it produces smooth-walled strain as well as rough-walled strain.
• The smooth-walled strain has a polysaccharide coating and is also disease-causing.
• When S Strain is injected mice die whereas when R strain is injected mice do not die. And when S heat-killed is injected mice remain alive. 
• But, when S heat-killed and R strain is injected into mice, Mice die.
• Hence the conclusion is R strain bacteria transformed by heat-killed S strain.