A 5-year-old child with ALL is started on a chemotherapy protocol which includes Prednisolone. Which of the following side effects of this medication is to be anticipated?

Question

Question

Answer 1

Correct Answer: Mood changes

Rationale:

Prednisolone is a corticosteroid medication commonly used in chemotherapy protocols for conditions like Acute Lymphoblastic Leukemia (ALL). It works by suppressing the immune system and inflammation.
One of the well-known side effects of corticosteroids like Prednisolone is mood changes. These mood changes can include symptoms such as irritability, anxiety, euphoria, and even depression.
The mood changes are due to the effect of corticosteroids on the central nervous system, altering neurotransmitter levels and affecting mood regulation.

Explanation of Other Options:

Alopecia

Rationale: Alopecia, or hair loss, is commonly associated with chemotherapy agents like alkylating agents and antimetabolites, rather than corticosteroids like Prednisolone.

Anorexia

Rationale: Anorexia, or loss of appetite, is not a typical side effect of Prednisolone. In fact, corticosteroids can increase appetite rather than suppress it.

Weight loss

Rationale: Weight loss is not commonly associated with Prednisolone. Instead, corticosteroids can lead to weight gain due to increased appetite and fluid retention.

Conclusion:

Among the given options, mood changes are the anticipated side effect when a 5-year-old child with ALL is started on a chemotherapy protocol that includes Prednisolone. Mood changes are a common and significant side effect of corticosteroid therapy due to their impact on the central nervous system.